Introduction: Patient comfort measurement tools are recognized as a key tool in assessing the quality of healthcare services. These tools help us identify patients' needs and expectations and ultimately have a direct impact on patient experience, collaboration in treatment, and improvement of health status and quality of care. This study aims to systematically review various patient comfort measurement tools, their validity and reliability across different studies, challenges in using these tools, and solutions for improvement .Methods: In this systematic review, articles published between 2015 and 2025 in databases including PubMed, Scopus, Web of Science, Google Scholar, and SID were reviewed. The keywords used included "patient comfort measurement tools," "patient comfort," "reliability and validity," and other related terms. Articles in English and Persian that reviewed patient comfort measurement tools were selected. Review articles, posters, letters to the editor, and qualitative studies were the exclusion criteria.Results: The results of the review of 21 studies showed that patient comfort measurement tools include questionnaires, scales, and mixed methods designed to measure different aspects of the patient experience. The main challenges in using these tools included non-compliance with specific patient needs, problems related to the validity and reliability of the tools, lack of training for staff, and lack of active patient participation in the assessment process. Also, improvement strategies were suggested, including designing localized tools, continuous staff training, increasing patient awareness, and using modern technologies for data collection .Conclusion: Each tool has characteristics that distinguish it from other tools. Choosing the right tool depends on various factors. Furthermore, the effective use of patient comfort measurement tools requires attention to existing challenges and implementation of appropriate solutions. Improving the quality of these tools and integrating them into clinical processes can lead to increased patient satisfaction and improved quality of health services. Active patient participation and ongoing staff training are also key factors in the success of these tools.